Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/33025
Title: Treating the exercise problem in COPD
Authors: Steiner, Michael C.
Greening, Neil J.
First Published: Oct-2014
Publisher: American College of Chest Physicians (ACCP)
Citation: Chest, 2014, 146 (4), pp. 878-880
Abstract: The inability to be physically active is one of the key complaints expressed by patients with COPD. This is best considered as an exercise problem because it is the quantitative restriction to physical capacity more than the sensation of breathlessness or fatigue during exercise (something we all experience) that is the abnormal symptom. There is now a convincing body of evidence indicating that skeletal muscle dysfunction is a frequent and clinically relevant feature of COPD that contributes significantly to reduced exercise performance and, indeed, mortality independently from the severity of lung function impairment.1 The cause of this dysfunction has been debated, but a long-term downward spiral of inactivity and deconditioning is the key feature of its natural history, although other disease-related factors (eg, hypoxia, drug therapy, systemic inflammation) may contribute in selected patients.[opening paragraph]
DOI Link: 10.1378/chest.14-0654
ISSN: 0012-3692
eISSN: 1931-3543
Links: http://journal.publications.chestnet.org/article.aspx?articleid=1912461
http://hdl.handle.net/2381/33025
Embargo on file until: 1-Jan-10000
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2014, American College of Chest Physicians (ACCP).
Description: The file associated with this record is embargoed while permission to archive is sought from the publisher. The final published version may be available through the links above.
Appears in Collections:Published Articles, College of Medicine, Biological Sciences and Psychology

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