Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/33025
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dc.contributor.authorSteiner, Michael C.-
dc.contributor.authorGreening, Neil J.-
dc.date.accessioned2015-09-04T13:58:18Z-
dc.date.issued2014-10-
dc.identifier.citationChest, 2014, 146 (4), pp. 878-880en
dc.identifier.issn0012-3692-
dc.identifier.urihttp://journal.publications.chestnet.org/article.aspx?articleid=1912461en
dc.identifier.urihttp://hdl.handle.net/2381/33025-
dc.descriptionThe file associated with this record is embargoed while permission to archive is sought from the publisher. The final published version may be available through the links above.en
dc.description.abstractThe inability to be physically active is one of the key complaints expressed by patients with COPD. This is best considered as an exercise problem because it is the quantitative restriction to physical capacity more than the sensation of breathlessness or fatigue during exercise (something we all experience) that is the abnormal symptom. There is now a convincing body of evidence indicating that skeletal muscle dysfunction is a frequent and clinically relevant feature of COPD that contributes significantly to reduced exercise performance and, indeed, mortality independently from the severity of lung function impairment.1 The cause of this dysfunction has been debated, but a long-term downward spiral of inactivity and deconditioning is the key feature of its natural history, although other disease-related factors (eg, hypoxia, drug therapy, systemic inflammation) may contribute in selected patients.[opening paragraph]en
dc.language.isoenen
dc.publisherAmerican College of Chest Physicians (ACCP)en
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/25287996-
dc.rightsCopyright © 2014, American College of Chest Physicians (ACCP).en
dc.subjectAngiotensin-Converting Enzyme Inhibitorsen
dc.subjectFemaleen
dc.subjectFosinoprilen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectPulmonary Disease, Chronic Obstructiveen
dc.subjectQuadriceps Muscleen
dc.titleTreating the exercise problem in COPDen
dc.typeJournal Articleen
dc.identifier.doi10.1378/chest.14-0654-
dc.identifier.eissn1931-3543-
dc.identifier.pii1912461-
dc.description.statusPeer-revieweden
dc.description.versionPublisher Versionen
dc.type.subtypeComment;Editorial-
pubs.organisational-group/Organisationen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGYen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicineen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and Inflammationen
dc.rights.embargodate10000-01-01-
Appears in Collections:Published Articles, College of Medicine, Biological Sciences and Psychology

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