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Title: Simulating biologically plausible complex survival data
Authors: Crowther, Michael J.
Lambert, P. C.
First Published: 23-Apr-2013
Citation: Statistics in Medicine, 2013, 32 (23), pp. 4118-4134
Abstract: Simulation studies are conducted to assess the performance of current and novel statistical models in pre-defined scenarios. It is often desirable that chosen simulation scenarios accurately reflect a biologically plausible underlying distribution. This is particularly important in the framework of survival analysis, where simulated distributions are chosen for both the event time and the censoring time. This paper develops methods for using complex distributions when generating survival times to assess methods in practice. We describe a general algorithm involving numerical integration and root-finding techniques to generate survival times from a variety of complex parametric distributions, incorporating any combination of time-dependent effects, time-varying covariates, delayed entry, random effects and covariates measured with error. User-friendly Stata software is provided. Copyright © 2013 John Wiley & Sons, Ltd.
DOI Link: 10.1002/sim.5823
ISSN: 0277-6715
eISSN: 1097-0258
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2013 John Wiley & Sons, Ltd. This is the peer reviewed version of the following article: Crowther, M. J. and Lambert, P. C. (2013), Simulating biologically plausible complex survival data. Statist. Med., 32: 4118–4134, which has been published in final form at . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
Appears in Collections:Published Articles, Dept. of Health Sciences

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