Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/33088
Title: Graphical augmentations to the funnel plot to assess the impact of a new study on an existing meta-analysis
Authors: Crowther, Michael J.
Langan, D.
Sutton, A. J.
First Published: 1-Jan-2012
Publisher: Stata Press
Citation: Stata Journal, 2012, 12 (4), pp. 605-622 (18)
Abstract: Funnel plots are currently advocated to investigate the presence of publication bias (and other possible sources of bias) in meta-analysis. A previously described augmentation to the funnel plot—to aid its interpretation in assessing publication biases—is the addition of statistical contours indicating regions where studies would have to be for a given level of significance, as implemented in the Stata package confunnel by Palmer et al. (2008, Stata Journal 8: 242–254). In this article, we describe the implementation of a new range of overlay augmentations to the funnel plot, many described in detail recently by Langan et al. (2012, Journal of Clinical Epidemiology 65: 511–519). The purpose of these overlays is to display the potential impact a new study would have on an existing meta-analysis, providing an indication of the robustness of the meta-analysis to the addition of new evidence. Thus these overlays extend the use of the funnel plot beyond assessments of publication biases. Two main graphical displays are described: 1) statistical significance contours, which define regions of the funnel plot where a new study would have to be located to change the statistical significance of the meta-analysis; and 2) heterogeneity contours, which show how a new study would affect the extent of heterogeneity in a given meta-analysis. We present the extfunnel command, which implements the methods of Langan et al. (2012, Journal of Clinical Epidemiology 65: 511–519), and, furthermore, we extend the graphical displays to illustrate the impact a new study has on lower and upper confidence interval values and the confidence interval width of the pooled meta-analytic result. We also describe overlays for the impact of a future study on user-defined limits of clinical equivalence. We implement inversevariance weighted methods by using both explicit formulas for contour lines and a simulation approach optimized in Mata.
ISSN: 1536-867X
Links: http://www.stata-journal.com/article.html?article=gr0054
http://hdl.handle.net/2381/33088
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2012, StataCorp. Made available with kind permission by the publisher.
Appears in Collections:Published Articles, Dept. of Health Sciences

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