Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/33198
Title: Haptoglobin (HP) and Haptoglobin-related protein (HPR) copy number variation, natural selection, and trypanosomiasis
Authors: Hardwick, R. J.
Ménard, A.
Sironi, M.
Milet, J.
Garcia, A.
Sese, C.
Yang, F.
Fu, B.
Courtin, D.
Hollox, Ed J.
First Published: 5-Sep-2013
Citation: Hum Genet, 2014, 133 (1), pp. 69-83
Abstract: Haptoglobin, coded by the HP gene, is a plasma protein that acts as a scavenger for free heme, and haptoglobin-related protein (coded by the HPR gene) forms part of the trypanolytic factor TLF-1, together with apolipoprotein L1 (ApoL1). We analyse the polymorphic small intragenic duplication of the HP gene, with alleles Hp1 and Hp2, in 52 populations, and find no evidence for natural selection either from extended haplotype analysis or from correlation with pathogen richness matrices. Using fiber-FISH, the paralog ratio test, and array-CGH data, we also confirm that the HPR gene is copy number variable, with duplication of the whole HPR gene at polymorphic frequencies in west and central Africa, up to an allele frequency of 15 %. The geographical distribution of the HPR duplication allele overlaps the region where the pathogen causing chronic human African trypanosomiasis, Trypanosoma brucei gambiense, is endemic. The HPR duplication has occurred on one SNP haplotype, but there is no strong evidence of extended homozygosity, a characteristic of recent natural selection. The HPR duplication shows a slight, non-significant undertransmission to human African trypanosomiasis-affected children of unaffected parents in the Democratic Republic of Congo. However, taken together with alleles of APOL1, there is an overall significant undertransmission of putative protective alleles to human African trypanosomiasis-affected children.
DOI Link: 10.1007/s00439-013-1352-x
eISSN: 1432-1203
Links: http://link.springer.com/article/10.1007%2Fs00439-013-1352-x
http://hdl.handle.net/2381/33198
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright ©the author(s) 2013. This article is published with open access at springerlink.com. Deposited in accordance with the Publisher's self-archiving policy available at http://www.springer.com/gp/open-access/authors-rights/self-archiving-policy/2124
Appears in Collections:Published Articles, Dept. of Genetics

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