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Title: The logic of circadian organization in Drosophila
Authors: Dissel, S.
Hansen, C. N.
Özkaya, Ö.
Hemsley, M.
Kyriacou, Charalambos P.
Rosato, E.
First Published: 11-Sep-2014
Publisher: Elsevier (Cell Press)
Citation: Current Biology, 2014, 24 (19), pp. 2257-2266
Abstract: BACKGROUND: In the fruit fly Drosophila melanogaster, interlocked negative transcription/translation feedback loops provide the core of the circadian clock that generates rhythmic phenotypes. Although the current molecular model portrays the oscillator as cell autonomous, cross-talk among clock neurons is essential for robust cycling behavior. Nevertheless, the functional organization of the neuronal network remains obscure. RESULTS: Here we show that shortening or lengthening of the circadian period of locomotor activity can be obtained either by targeting different groups of clock cells with the same genetic manipulation or by challenging the same group of cells with activators and repressors of neuronal excitability. CONCLUSIONS: Based on these observations we interpret circadian rhythmicity as an emerging property of the circadian network and we propose an initial model for its architectural design.
DOI Link: 10.1016/j.cub.2014.08.023
eISSN: 1879-0445
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2013. This is an open-access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Appears in Collections:Published Articles, Dept. of Genetics

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