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Title: Serine and glycine metabolism in cancer
Authors: Amelio, Ivano
Cutruzzolá, F.
Antonov, Alexey
Agostini, Massimiliano
Melino, Gerry
First Published: 20-Mar-2014
Publisher: Elsevier (Cell Press)
Citation: Trends in Biochemical Sciences, 2014, 39(4), 191–198
Abstract: Serine and glycine are biosynthetically linked, and together provide the essential precursors for the synthesis of proteins, nucleic acids, and lipids that are crucial to cancer cell growth. Moreover, serine/glycine biosynthesis also affects cellular antioxidative capacity, thus supporting tumour homeostasis. A crucial contribution of serine/glycine to cellular metabolism is through the glycine cleavage system, which refuels one-carbon metabolism; a complex cyclic metabolic network based on chemical reactions of folate compounds. The importance of serine/glycine metabolism is further highlighted by genetic and functional evidence indicating that hyperactivation of the serine/glycine biosynthetic pathway drives oncogenesis. Recent developments in our understanding of these pathways provide novel translational opportunities for drug development, dietary intervention, and biomarker identification of human cancers.
DOI Link: 10.1016/j.tibs.2014.02.004
ISSN: 0968-0004
eISSN: 0167-7640
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Crown Copyright © 2014 Published by Elsevier Ltd. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License ( ), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Appears in Collections:Published Articles, MRC Toxicology Unit

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