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Title: Connexin40 regulates platelet function
Authors: Vaiyapuri, S.
Moraes, L. A.
Sage, T.
Ali, M. S.
Lewis, K. R.
Mahaut-Smith, Martyn P.
Oviedo-Orta, E.
Simon, A. M.
Gibbins, J. M.
First Published: 7-Oct-2013
Publisher: Nature Publishing Group
Citation: Nature Communications, 2013, 4, 2564
Abstract: The presence of multiple connexins was recently demonstrated in platelets, with notable expression of Cx37. Studies with Cx37-deficient mice and connexin inhibitors established roles for hemichannels and gap junctions in platelet function. It was uncertain, however, whether Cx37 functions alone or in collaboration with other family members through heteromeric interactions in regulation of platelet function. Here we report the presence and functions of an additional platelet connexin, Cx40. Inhibition of Cx40 in human platelets or its deletion in mice reduces platelet aggregation, fibrinogen binding, granule secretion and clot retraction. The effects of the Cx37 inhibitor [superscript: 37,43]Gap27 on Cx40[superscript: -/-] mouse platelets and of the Cx40 inhibitor [superscript: 40]Gap27 on Cx37[superscript: -/-] mouse platelets revealed that each connexin is able to function independently. Inhibition or deletion of Cx40 reduces haemostatic responses in mice, indicating the physiological importance of this protein in platelets. We conclude that multiple connexins are involved in regulating platelet function, thereby contributing to haemostasis and thrombosis.
DOI Link: 10.1038/ncomms3564
eISSN: 2041-1723
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2013, Rights Managed by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit
Appears in Collections:Published Articles, Dept. of Cell Physiology and Pharmacology

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