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Title: Selective vancomycin detection using optical fibre long period gratings functionalised with molecularly imprinted polymer nanoparticles
Authors: Korposh, S.
Chianella, I.
Guerreiro, Antonio
Caygill, S.
Piletsky, S.
James, S. W.
Tatam, R. P.
First Published: 7-May-2014
Publisher: Royal Society of Chemistry
Citation: Analyst, 2014, 139 (9), pp. 2229-2236
Abstract: An optical fibre long period grating (LPG) sensor modified with molecularly imprinted polymer nanoparticles (nanoMIPs) for the specific detection of antibiotics is presented. The operation of the sensor is based on the measurement of changes in refractive index induced by the interaction of nanoMIPs deposited onto the cladding of the LPG with free vancomycin (VA). The binding of nanoMIPs to vancomycin was characterised by a binding constant of 4.3 ± 0.1 × 10(-8) M. The lowest concentration of analyte measured by the fibre sensor was 10 nM. In addition, the sensor exhibited selectivity, as much smaller responses were obtained for high concentrations (∼700 μM) of other commonly prescribed antibiotics such as amoxicillin, bleomycin and gentamicin. In addition, the response of the sensor was characterised in a complex matrix, porcine plasma, spiked with 10 μM of VA.
DOI Link: 10.1039/c3an02126b
eISSN: 1364-5528
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © The Royal Society of Chemistry 2014. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence
Appears in Collections:Published Articles, Dept. of Chemistry

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