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Title: High quality de novo sequencing and assembly of the Saccharomyces arboricolus genome
Authors: Liti, G.
Nguyen Ba, A. N.
Blythe, M.
Müller, C. A.
Bergström, A.
Cubillos, F. A.
Dafhnis-Calas, F.
Khoshraftar, S.
Malla, S.
Mehta, N.
Siow, C.C.
Warringer, J.
Moses, A. M.
Louis, Edward John
Nieduszynski, C. A.
First Published: 31-Jan-2013
Publisher: BioMed Central
Citation: BMC Genomics, 2013, 14, 69
Abstract: BACKGROUND: Comparative genomics is a formidable tool to identify functional elements throughout a genome. In the past ten years, studies in the budding yeast Saccharomyces cerevisiae and a set of closely related species have been instrumental in showing the benefit of analyzing patterns of sequence conservation. Increasing the number of closely related genome sequences makes the comparative genomics approach more powerful and accurate. RESULTS: Here, we report the genome sequence and analysis of Saccharomyces arboricolus, a yeast species recently isolated in China, that is closely related to S. cerevisiae. We obtained high quality de novo sequence and assemblies using a combination of next generation sequencing technologies, established the phylogenetic position of this species and considered its phenotypic profile under multiple environmental conditions in the light of its gene content and phylogeny. CONCLUSIONS: We suggest that the genome of S. arboricolus will be useful in future comparative genomics analysis of the Saccharomyces sensu stricto yeasts.
DOI Link: 10.1186/1471-2164-14-69
eISSN: 1471-2164
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2013 Liti et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:Published Articles, Dept. of Genetics

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