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Title: Surface-modified multifunctional MIP nanoparticles
Authors: Moczko, Ewa
Poma, Alessandro
Guerreiro, Antonio
de Vargas Sansalvador, Isabel Perez
Caygil, Sarah
Canfarotta, Francesco
Whitcombe, Michael J.
Piletsky, Sergey
First Published: 23-Feb-2013
Publisher: Royal Society of Chemistry
Citation: Nanoscale, 2013,5, pp. 3733-3741
Abstract: The synthesis of core–shell molecularly imprinted polymer nanoparticles (MIP NPs) has been performed using a novel solid-phase approach on immobilised templates. The same solid phase also acts as a protective functionality for high affinity binding sites during subsequent derivatisation/shell formation. This procedure allows for the rapid synthesis, controlled separation and purification of high-affinity materials, with each production cycle taking just 2 hours. The aim of this approach is to synthesise uniformly sized imprinted materials at the nanoscale which can be readily grafted with various polymers without affecting their affinity and specificity. For demonstration purposes we grafted anti-melamine MIP NPs with coatings which introduce the following surface characteristics: high polarity (PEG methacrylate); electro-activity (vinylferrocene); fluorescence (eosin acrylate); thiol groups (pentaerythritol tetrakis(3-mercaptopropionate)). The method has broad applicability and can be used to produce multifunctional imprinted nanoparticles with potential for further application in the biosensors, diagnostics and biomedical fields and as an alternative to natural receptors.
DOI Link: 10.1039/C3NR00354J
ISSN: 2040-3364
eISSN: 2040-3372
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2013, Royal Society of Chemistry. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.
Appears in Collections:Published Articles, Dept. of Chemistry

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Supplementary_Information - Surface-modified multifunctional MIP nanoparticles - Nanoscale - OA.pdfElectronic Supplementary Information (ESI)457.57 kBAdobe PDFView/Open

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