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Title: Uncovering physiological mechanisms for health disparities in type 2 diabetes
Authors: Staiano, A. E.
Harrington, Deirdre M.
Johannsen, N. M.
Newton, R. L.
Sarzynski, M. A.
Swift, D. L.
Katzmarzyk, P. T.
First Published: 2015
Publisher: International Society on Hypertension in Blacks
Citation: Ethnicity and Disease , 2015, 25 (1), pp. 31-37
Abstract: Type 2 diabetes (T2D) prevalence in the United States is significantly higher in African Americans vs Whites. Yet, the physiological mechanisms contributing to this health disparity have been poorly described. To design effective strategies to reduce this disparity, there is a need to determine whether racial differences in diabetes prevalence are attributable to modifiable or non-modifiable factors. This review synthesizes and critically evaluates the potential physiological and genetic mechanisms that may contribute to the higher susceptibility of African Americans to T2D. These mechanisms include: 1) obesity and fat distribution; 2) metabolic flexibility; 3) muscle physiology; 4) energy expenditure and fitness; and 5) genetics. We focus on the clinical significance of findings and limitations of the recent literature.
ISSN: 1049-510X
Embargo on file until: 1-Jan-10000
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2015, International Society on Hypertension in Blacks. All rights reserved.
Description: The file associated with this record is under a permanent embargo while permission to archive is sought from the publisher. The full text may become available through the publisher links above.
Appears in Collections:Published Articles, College of Medicine, Biological Sciences and Psychology

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