Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/33512
Title: Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
Authors: Soler Artigas, María
Wain, Louise V.
Miller, Suzanne
Kheirallah, Abdul Kader
Huffman, Jennifer E.
Ntalla, Ioanna
Shrine, Nick
Obeidat, Ma'en
Trochet, Holly
McArdle, Wendy L.
Alves, Alexessander Couto
Hui, Jennie
Zhao, Jing Hua
Joshi, Peter K.
Teumer, Alexander
Albrecht, Eva
Imboden, Medea
Rawal, Rajesh
Lopez, Lorna M.
Marten, Jonathan
Enroth, Stefan
Surakka, Ida
Polasek, Ozren
Lyytikäinen, Leo-Pekka
Granell, Raquel
Hysi, Pirro G.
Flexeder, Claudia
Mahajan, Anubha
Beilby, John
Bossé, Yohan
Brandsma, Corry-Anke
Campbell, Harry
Gieger, Christian
Gläser, Sven
González, Juan R.
Grallert, Harald
Hammond, Chris J.
Harris, Sarah E.
Hartikainen, Anna-Liisa
Hayward, Caroline
Heliövaara, Markku
Henderson, John
Hocking, Lynne
Horikoshi, Momoko
Hutri-Kähönen, Nina
Ingelsson, Erik
Johansson, Åsa
Kemp, John P.
Kolcic, Ivana
Kumar, Ashish
Lind, Lars
Melén, Erik
Musk, Arthur W.
Navarro, Pau
Nickle, David C.
Padmanabhan, Sandosh
Raitakari, Olli T.
Ried, Janina S.
Ripatti, Samuli
Schulz, Holger
Scott, Robert A.
Sin, Don D.
Starr, John M.
Viñuela, Ana
Völzke, Henry
Wild, Sarah H.
Wright, Alan F.
Zemunik, Tatijana
Jarvis, Deborah L.
Spector, Tim D.
Evans, David M.
Lehtimäki, Terho
Vitart, Veronique
Kähönen, Mika
Gyllensten, Ulf
Rudan, Igor
Deary, Ian J.
Karrasch, Stefan
Probst-Hensch, Nicole M.
Heinrich, Joachim
Koch, Beate
Wilson, James F.
Wareham, Nicholas J.
James, Alan L.
Morris, Andrew P.
Jarvelin, Marjo-Riitta
Sayers, Ian
Strachan, David P.
Hall, Ian P.
Tobin, Martin D.
UK BiLEVE
Generation Scotland
First Published: 2015
Publisher: Nature Publishing Group
Citation: Nature Communications, 2015, in press
Abstract: Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (Phase 1) imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5x10-8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1, AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.
DOI Link: TBC
eISSN: 2041-1723
Links: http://www.nature.com/ncomms/index.html
http://hdl.handle.net/2381/33512
Embargo on file until: 1-Jan-10000
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: x
Description: This file is under embargo until the date of publication.
Appears in Collections:Published Articles, Dept. of Health Sciences

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