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|Title:||Intramolecular Fluorocyclizations of Unsaturated Carboxylic Acids with a Stable Hypervalent Fluoroiodane Reagent|
|Authors:||Geary, Gemma C.|
Hope, Eric G.
Stuart, Alison M.
|Citation:||Angewandte Chemie International Edition, 2015 (Early View, In press)|
|Abstract:||A new class of fluorinated lactones was prepared by the intramolecular fluorocyclizations of unsaturated carboxylic acids by using the stable fluoroiodane reagent in combination with AgBF4 . This unique reaction incorporates a cyclization, an aryl migration, and a fluorination all in one step. The fluoroiodane reagent, prepared easily from fluoride, can also be used without a metal catalyst to give moderate yields within just 1 hour, thus demonstrating that it is a suitable reagent for developing new (18) F-labelled radiotracers for PET imaging.|
|Rights:||Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the accepted version of the following article: Geary, G. C., Hope, E. G. and Stuart, A. M. (2015), Intramolecular Fluorocyclizations of Unsaturated Carboxylic Acids with a Stable Hypervalent Fluoroiodane Reagent. Angew. Chem. Int. Ed.. doi:10.1002/anie.201507790, which has been published in final form at doi: 10.1002/anie.201507790|
|Description:||The file associated with this record is under a 12-month embargo from publication in accordance with the publisher Copyright transfer agreement, available at http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291521-3773/homepage/2002_authors.html. The full text may be available through the publisher links provided above.|
|Appears in Collections:||Published Articles, Dept. of Chemistry|
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|Fluorocyclizations (Revised manuscript_f).pdf||Post-review (final submitted)||519.83 kB||Adobe PDF||View/Open|
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