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Title: Caspase-9 cleavage: do you need it
Authors: Twiddy, Davina
Cain, Kelvin
First Published: 1-Jul-2007
Publisher: Portland Press
Citation: Biochemical Journal, 2007, 405(1), e1-2
Abstract: Caspase-9 which is activated by association with the Apaf-1 apoptosome complex cleaves and activates the downstream effector caspases-3 and -7, thereby executing the caspase-cascade and cell death programme. Although, caspase-9 does not need to be cleaved to be active, apoptotic cell death is always accompanied by autocatalytic cleavage and by further downstream effector caspase-dependent cleavage of caspase-9. In this issue of the Biochemical Journal, Denault and co-workers evaluate the role of caspase-3-dependent cleavage of caspase-9 and conclude that this mechanism mainly serves to enhance apoptosis by alleviating XIAP inhibition of the apical caspase.
Type: Article
Description: This is the authors' final draft of the commentary published as Biochemical Journal, 2007, 405(1), e1-2, and available from
Appears in Collections:Published Articles, MRC Toxicology Unit

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