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|Title:||Homochiral synthesis of paraconic acid and the biosynthesis of amphotericin B.|
|Authors:||Crawforth, James Michael.|
|Presented at:||University of Leicester|
|Abstract:||Homochiral (S)-(-)-paraconic acid was synthesised in 18% overall yield from (45)-4-isopropyl-2-oxazolidinone using titanium enolate methodology. Paraconic acid was used to synthesise A-factor. A-factor and analogues were fed to a culture of Streptomyces nodosus however no definitive enhancement, or a decrease in the lag time for the onset of metabolite production was observed. Sodium acetate-d3, [1-13C] and [3-13C]-propionate were fed to a culture of Streptomyces nodosus and label incorporation into amphotericin B of 10-15% was observed.|
|Rights:||Copyright © the author. All rights reserved.|
|Appears in Collections:||Theses, Dept. of Chemistry|
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