Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/34068
Full metadata record
DC FieldValueLanguage
dc.contributor.authorCrawforth, James Michael.en
dc.date.accessioned2015-11-19T08:49:07Z-
dc.date.available2015-11-19T08:49:07Z-
dc.date.issued1996en
dc.identifier.urihttp://hdl.handle.net/2381/34068-
dc.description.abstractHomochiral (S)-(-)-paraconic acid was synthesised in 18% overall yield from (45)-4-isopropyl-2-oxazolidinone using titanium enolate methodology. Paraconic acid was used to synthesise A-factor. A-factor and analogues were fed to a culture of Streptomyces nodosus however no definitive enhancement, or a decrease in the lag time for the onset of metabolite production was observed. Sodium acetate-d3, [1-13C] and [3-13C]-propionate were fed to a culture of Streptomyces nodosus and label incorporation into amphotericin B of 10-15% was observed.en
dc.language.isoenen
dc.rightsCopyright © the author. All rights reserved.en
dc.sourceProQuesten
dc.titleHomochiral synthesis of paraconic acid and the biosynthesis of amphotericin B.en
dc.typeThesisen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePh.D.en
dc.date.award1996en
dc.publisher.departmentChemistryen
dc.publisher.institutionUniversity of Leicesteren
dc.identifier.proquestU085099en
dc.identifier.cataloguecontrolx753594675en
Appears in Collections:Theses, Dept. of Chemistry
Leicester Theses

Files in This Item:
File Description SizeFormat 
U085099.pdf13.41 MBAdobe PDFView/Open


Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.