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Title: Exonization of active mouse LIs: a driver of transcriptome evolution?
Authors: Zemojtel, Tomasz
Penzkofe, Tobias
Schultz, Jorg
Dandekar, Thomas
Badge, Richard M.
Vingron, Martin
First Published: 26-Oct-2007
Publisher: BioMed Central Ltd
Citation: BMC Genomics, 2007, 8:392
Abstract: Background:Long interspersed nuclear elements (LINE-1s, L1s) have been recently implicated in the regulation of mammalian transcriptomes. Results:Here, we show that members of the three active mouse L1 subfamilies (A, G[subscript F] and T[subscript F]) contain, in addition to those on their sense strands, conserved functional splice sites on their antisense strands, which trigger multiple exonization events. The latter is particularly intriguing in the light of the strong antisense orientation bias of intronic L1s, implying that the toleration of antisense insertions results in an increased potential for exonization. Conclusion:In a genome-wide analysis, we have uncovered evidence suggesting that the mobility of the large number of retrotransposition-competent mouse L1s (~2400 potentially active L1s in NCBIm35) has significant potential to shape the mouse transcriptome by continuously generating insertions into transcriptional units.
DOI Link: 10.1186/1471-2164-8-392
eISSN: 1471-2164
Version: Publisher Version
Status: Peer-reviewed
Type: Article
Rights: Copyright © 2007 Zemojtel et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:Published Articles, Dept. of Genetics

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