Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/35385
Title: A molecular analysis of Escherichia coli cell surface antigens required for the colonisation of the urinary tract.
Authors: High, Nicola Jane.
Award date: 1988
Presented at: University of Leicester
Abstract: The uropathogenic Escherichia coli strain 20025 (04:K12:H-) elaborates at least four fimbrial antigens, Fy (F14), F12-rel, F13, F1C and secretes the toxin a-haemolysin. The work presented in this thesis demonstrates that the gene clusters encoding these five determinants are located within a 60-70kb region of the 20025 chromosome. The F14 fimbrial antigen produced by 20025 is a novel P-fimbriae serotype and exhibits a different binding specificity to the majority of P-fimbriae. To determine the basis of this apparent difference in cell surface receptor specificty a detailed molecular analysis of the F14 gene cluster is presented. The cloning and analysis of two other Escherichia coli surface antigens, the non-fimbrial adhesin NFA-1 and the K12 capsular polysaccharide is also described.
Links: http://hdl.handle.net/2381/35385
Type: Thesis
Level: Doctoral
Qualification: Ph.D.
Rights: Copyright © the author. All rights reserved.
Appears in Collections:Theses, Dept. of Biology
Leicester Theses

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