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Title: Recent male-mediated gene flow over a linguistic barrier in Iberia, suggested by analysis of a Y-chromosomal DNA polymorphism
Authors: Hurles, Matthew E.
Veitia, R.
Arroyo, Eduardo
Armenteros, M.
Bertranpetit, J.
Perez-Lezaun, A.
Bosch, Elena
Shlumukova, M.
Cambon-Thomsen, A.
McElreavey, Ken
Lopez De Munain, A.
Rohl, A.
Wilson, I.J.
Singh, L.
Pandya, Arpita
Santos, Fabricio R.
Tyler-Smith, Chris
Jobling, Mark A.
First Published: 1999
Publisher: University of Chicago Press
Citation: American Journal of Human Genetics, 1999, 65, pp. 1437-1448.
Abstract: We have examined the worldwide distribution of a Y-chromosomal base-substitution polymorphism, the T/C transition at SRY-2627, where the T allele defines haplogroup 22; sequencing of primate homologues shows that the ancestral state cannot be determined unambiguously but is probably the C allele. Of 1,191 human Y chromosomes analyzed, 33 belong to haplogroup 22. Twenty-nine come from Iberia, and the highest frequencies are in Basques (11%; n=117) and Catalans (22%; n=32). Microsatellite and minisatellite (MSY1) diversity analysis shows that non-Iberian haplogroup-22 chromosomes are not significantly different from Iberian ones. The simplest interpretation of these data is that haplogroup 22 arose in Iberia and that non-Iberian cases reflect Iberian emigrants. Several different methods were used to date the origin of the polymorphism: microsatellite data gave ages of 1,650, 2,700, 3,100, or 3,450 years, and MSY1 gave ages of 1,000, 2,300, or 2,650 years, although 95% confidence intervals on all of these figures are wide. The age of the split between Basque and Catalan haplogroup-22 chromosomes was calculated as only 20% of the age of the lineage as a whole. This study thus provides evidence for direct or indirect gene flow over the substantial linguistic barrier between the Indo-European and non-Indo-European-speaking populations of the Catalans and the Basques, during the past few thousand years.
Type: Article
Description: This is the version as published in the American Journal of Human Genetics by the University Of Chicago Press. Their website is
Appears in Collections:Published Articles, Dept. of Genetics

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