Please use this identifier to cite or link to this item:
Title: Modelling the non-linear motion of the rat central airways
Authors: Ibrahim, Gihad
Rona, Aldo
Hainsworth, Sarah V.
First Published: 23-Nov-2015
Publisher: American Society of Mechanical Engineers
Citation: Journal of Biomechanical Engineering, 2015 (In press)
Abstract: Advances in volumetric medical imaging techniques allowed the subject-specific modelling of the bronchial flow through the first few generations of the central airways using computational fluid dynamics (CFD). However, a reliable CFD prediction of the bronchial flow requires modelling of the inhomogeneous deformation of the central airways during breathing. This paper addresses this issue by introducing two models of the central airways motion. The first model utilises a node-to-node mapping between the discretised geometries of the central airways generated from a number of successive CT images acquired dynamically (without breath hold) over the breathing cycle of two Sprauge-Dawley rats. The second model uses a node-to-node mapping between only two discretised airway geometries generated from the CT images acquired at end-exhale and at end-inhale along with the ventilator measurement of the lung volume change. The advantage of this second model is that it uses just one pair of CT images, which more readily complies with the radiation dosage restrictions for humans. Three-dimensional computer aided design geometries of the central airways generated from the dynamic-CT images were used as benchmarks to validate the output from the two models at sampled time-points over the breathing cycle. The central airway geometries deformed by the first model showed good agreement to the benchmark geometries within a tolerance of 4%. The central airway geometry deformed by the second model better approximated the benchmark geometries than previous approaches that used a linear or harmonic motion model.
DOI Link: 10.1115/1.4032051
ISSN: 1528-8951
eISSN: 1528-8951
Embargo on file until: 1-Jan-10000
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2015 by ASME. All rights reserved.
Description: The file associated with this record is under a permanent embargo in accordance with the publisher's copyright policy, available at The full text may be available through the links provided above.
Appears in Collections:Published Articles, Dept. of Engineering

Files in This Item:
File Description SizeFormat 
BIO-14-1468 _COMPLETE_PAPER.pdfPost-review (final submitted)1.48 MBAdobe PDFView/Open

Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.