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|Title:||Familial Persistent Hyperinsulinemic Hypoglycemia of Infancy and Mutations in the Sulfonylurea Receptor|
|Authors:||Dunne, M. J.|
Shepherd, R. M.
Sanchez, J. A.
James, Roger F. L.
Johnson, Paul R. V.
Clement, J. P.
Lindley, K. J.
Milla, P. J.
|Publisher:||Massachusetts Medical Society|
|Citation:||New England Journal of Medicine 1997; 336:703-706|
|Abstract:||[1st paragraph] Persistent hyperinsulinemic hypoglycemia of infancy is caused by inappropriate and excessive secretion of insulin. Although the disease is rare in outbred communities (approximately 1 case per 50,000 persons), the incidence is approximately 1 per 2500 in inbred Arabic communities in which there is a familial (autosomal recessive) form of the disease. The disease most commonly presents with severe hypoglycemia a few hours after birth, although some cases present after several weeks or months. Some patients have a response to treatment with diazoxide or somatostatin, but others require partial pancreatectomy to control the hyperinsulinism.|
|Rights:||Archived with reference to SHERPA/RoMEO and publisher website.|
|Appears in Collections:||Published Articles, College of Medicine, Biological Sciences and Psychology|
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