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Title: Disease stage, but not sex, predicts depression and psychological distress in Huntington’s disease : A European population study
Authors: Dale, Maria
Maltby, John Julian
Shimozaki, S.
Cramp, R.
Rickards, H.
REGISTRY investigators of the European Huntington’s Disease Network
First Published: 12-Nov-2015
Publisher: Elsevier for European Association for Consultation-Liaison Psychiatry and Psychosomatics
Citation: Journal of Psychosomatic Research, 2016, 80, pp. 17–22
Abstract: Objective Depression and anxiety significantly affect morbidity in Huntington’s disease. Mice models of Huntington’s disease have identified sex differences in mood-like behaviours that vary across disease lifespan, but this interaction has not previously been explored in humans with Huntington’s disease. However, among certain medical populations, evidence of sex differences in mood across various disease stages has been found, reflecting trends among the general population that women tend to experience anxiety and depression 1.5 to 2 times more than men. The current study examined whether disease stage and sex, either separately or as an interaction term, predicted anxiety and depression in Huntington’s disease. Methods A cross-sectional study of REGISTRY data involving 453 Huntington’s disease participants from 12 European countries was undertaken using the Hospital Anxiety and Depression Scale. A series of multiple regression analyses were undertaken to discover to what extent disease stage and sex predicted anxiety, depression, and general distress after controlling for a number of known predictors of mood difficulties. Results Disease stage, but not sex, was found to predict depressive symptoms and general distress. Neither disease stage nor sex predicted anxiety. Furthermore, an interaction term computed for disease stage and sex did not contribute to the models tested. Conclusion In terms of considering risks to developing depression and anxiety in the Huntington’s disease population, practitioners may need to pay special attention to disease stage progression (but not sex differences) to enable early detection and treatment of depression (but not anxiety).
DOI Link: 10.1016/j.jpsychores.2015.11.003
ISSN: 0022-3999
eISSN: 1879-1360
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2015 Elsevier Inc. All rights reserved. This manuscript version is made available after the end of the embargo period under the CC-BY-NC-ND 4.0 license
Description: The file associated with this record is under a 12-month embargo from publication in accordance with the publisher's self-archiving policy, available at The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, College of Medicine, Biological Sciences and Psychology

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