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Title: The dual origin of the Malagasy in island Southeast Asia and East Africa: evidence from maternal and paternal lineages
Authors: Hurles, Matthew E.
Sykes, Bryan C.
Jobling, Mark A.
Forster, Peter
First Published: 2005
Publisher: University of Chicago Press
Citation: American Journal of Human Genetics, 2005, 76, pp 894-901.
Abstract: Linguistic and archaeological evidence about the origins of the Malagasy, the indigenous peoples of Madagascar, points to mixed African and Indonesian ancestry. By contrast, genetic evidence about the origins of the Malagasy has hitherto remained partial and imprecise. We defined 26 Y-chromosomal lineages by typing 44 Y-chromosomal polymorphisms in 362 males from four different ethnic groups from Madagascar and 10 potential ancestral populations in Island Southeast Asia and the Pacific.We also compared mitochondrial sequence diversity in the Malagasy with a manually curated database of 19,371 hypervariable segment I sequences, incorporating both published and unpublished data.We could attribute every maternal and paternal lineage found in the Malagasy to a likely geographic origin. Here, we demonstrate approximately equal African and Indonesian contributions to both paternal and maternal Malagasy lineages. The most likely origin of the Asia-derived paternal lineages found in the Malagasy is Borneo. This agrees strikingly with the linguistic evidence that the languages spoken around the Barito River in southern Borneo are the closest extant relatives of Malagasy languages. As a result of their equally balanced admixed ancestry, the Malagasy may represent an ideal population in which to identify loci underlying complex traits of both anthropological and medical interest.
Type: Article
Description: The is the version as published in The American journal of Human Genetics by University of Chicago Press. Their website is http://www.journals.uchicago/AJHG/home.html
Appears in Collections:Published Articles, Dept. of Genetics

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