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Title: Eating difficulties in children born late and moderately preterm at 2 years of age: a prospective population-based cohort study
Authors: Johnson, Samantha J.
Matthews, R.
Draper, Elizabeth S.
Field, D. J.
Manktelow, B. N.
Marlow, N.
Smith, L. K.
Boyle, E. M.
First Published: 30-Dec-2015
Publisher: American Society for Nutrition
Citation: American Journal of Clinical Nutrition, 2016, 103(2), 406-414
Abstract: Background: Very preterm (<32 wk of gestation) infants are at increased risk of eating difficulties compared with their term-born peers. Little is known about the impact of late and moderately preterm (LMPT; 32–36 wk of gestation) birth on eating difficulties in early childhood. Objectives: The aims were to assess the prevalence of eating difficulties in infants born LMPT at 2 y corrected age and to explore the impact of neonatal and neurodevelopmental factors. Design: A geographic population-based cohort of 1130 LMPT and 1255 term-born controls was recruited at birth. The parents of 651 (59%) LMPT and 771 (62%) term-born infants completed questionnaires at 2 y corrected age to assess neurodevelopmental outcomes. Parents also completed a validated questionnaire to assess eating behaviors in 4 domains: refusal/picky eating, oral motor problems, oral hypersensitivity, and eating behavior problems. Infants with scores >90th percentile were classified with eating difficulties in each domain. Neonatal data were collected at discharge, and sociodemographic information was collected via maternal interview. Poisson regression was used to assess between-group differences in eating difficulties and to explore associations with neonatal factors and neurodevelopmental outcomes at 2 y of age. Results: In unadjusted analyses, LMPT infants were at increased risk of refusal/picky eating (RR: 1.53; 95% CI: 1.03, 2.25) and oral motor problems (RR: 1.62; 95% CI: 1.06, 2.47). Prolonged nasogastric feeding >2 wk (RR: 1.87; 95% CI: 1.07, 3.25), behavior problems (RR: 2.95; 95% CI: 1.93, 4.52), and delayed social competence (RR: 2.28; 95% CI: 1.49, 3.48) were independently associated with eating difficulties in multivariable analyses. After adjustment for these factors, there was no excess of eating difficulties in LMPT infants. Conclusions: Infants born LMPT are at increased risk of oral motor and picky eating problems at 2 y corrected age. However, these are mediated by other neurobehavioral sequelae in this population. This trial was registered on the UK Clinical Research Network Portfolio at as UKCRN Study ID 7441.
DOI Link: 10.3945/​ajcn.115.121061
ISSN: 0002-9165
eISSN: 1938-3207
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2015, American Society for Nutrition. All rights reserved. Deposited with reference to the publisher’s open access archiving policy: REF authors may post articles the Author's post-print in an institutional repository with a 12 months embargo.
Appears in Collections:Published Articles, Dept. of Health Sciences

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