Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/36002
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKulkarni, Neeta-
dc.contributor.authorPierse, Nevil-
dc.contributor.authorRushton, Lesley-
dc.contributor.authorGrigg, Jonathan-
dc.date.accessioned2015-12-07T11:31:15Z-
dc.date.available2015-12-07T11:31:15Z-
dc.date.issued2006-07-06-
dc.identifier.citationNew England Journal of Medicine, 2006, 355 (1), pp. 21-30en
dc.identifier.issn0028-4793-
dc.identifier.urihttp://www.nejm.org/doi/full/10.1056/NEJMoa052972en
dc.identifier.urihttp://hdl.handle.net/2381/36002-
dc.description.abstractBACKGROUND: Epidemiologic studies indirectly suggest that the inhalation of carbonaceous particulate matter impairs lung function in children. Using the carbon content of airway macrophages as a marker of individual exposure to particulate matter derived from fossil fuel, we sought direct evidence of this association. METHODS: Airway macrophages were obtained from healthy children through sputum induction, and the area of airway macrophages occupied by carbon was measured. Lung function was measured with the use of spirometry. We modeled the exposure to primary particulate matter (PM) that is less than 10 mum in aerodynamic diameter (PM10) at or near each child's home address. Linear regression was used to evaluate associations between carbon content of alveolar macrophages and variables that may affect individual exposure. To determine whether lung function that is reduced for other reasons is associated with an increase in the carbon content of airway macrophages, we also studied children with severe asthma. RESULTS: We were able to assess the carbon content of airway macrophages in 64 of 114 healthy children (56 percent). Each increase in primary PM10 of 1.0 microg per cubic meter was associated with an increase of 0.10 microm2 (95 percent confidence interval, 0.01 to 0.18) in the carbon content of airway macrophages, and each increase of 1.0 microm2 in carbon content was associated with a reduction of 17 percent (95 percent confidence interval, 5.6 to 28.4 percent) in forced expiratory volume in one second, of 12.9 percent (95 percent confidence interval, 0.9 to 24.8 percent) in forced vital capacity, and of 34.7 percent (95 percent confidence interval, 11.3 to 58.1 percent) in the forced expiratory flow between 25 and 75 percent of the forced vital capacity. The carbon content of airway macrophages was lower in children with asthma than in healthy children. CONCLUSIONS: There is a dose-dependent inverse association between the carbon content of airway macrophages and lung function in children. We found no evidence that reduced lung function itself causes an increase in carbon content.en
dc.language.isoenen
dc.publisherMassachusetts Medical Societyen
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/16822993-
dc.rightsArchived with reference to SHERPA/RoMEO and publisher website.en
dc.subjectAdolescenten
dc.subjectAir Pollutantsen
dc.subjectAsthmaen
dc.subjectCarbonen
dc.subjectChilden
dc.subjectDose-Response Relationship, Drugen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectLinear Modelsen
dc.subjectMacrophages, Alveolaren
dc.subjectMaleen
dc.subjectPulmonary Ventilationen
dc.subjectSputumen
dc.subjectVital Capacityen
dc.titleCarbon in airway macrophages and lung function in childrenen
dc.typeJournal Articleen
dc.identifier.doi10.1056/NEJMoa052972-
dc.identifier.eissn1533-4406-
dc.identifier.pii355/1/21-
dc.description.statusPeer-revieweden
dc.description.versionPublisher Versionen
dc.type.subtypeComparative Study;Journal Article;Research Support, Non-U.S. Gov't-
pubs.organisational-group/Organisationen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGYen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicineen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and Inflammationen
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

Files in This Item:
File Description SizeFormat 
nejmoa052972.pdfPublished (publisher PDF)381.84 kBAdobe PDFView/Open


Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.