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Title: Abnormal corticosteroid signalling in airway smooth muscle: mechanisms and perspectives for the treatment of severe asthma.
Authors: Chachi, L.
Gavrila, A.
Tliba, O.
Amrani, Yassine
First Published: 15-Oct-2015
Publisher: Wiley
Citation: Clinical and Experimental Allergy, 2015, 45 (11), pp. 1637-1646
Abstract: Growing in vivo evidence supports the concept that airway smooth muscle produces various immunomodulatory factors that could contribute to asthma pathogenesis via the regulation of airway inflammation, airway narrowing and remodelling. Targeting ASM using bronchial thermoplasty has provided undeniable clinical benefits for patients with uncontrolled severe asthma who are refractory to glucocorticoid therapy. The present review will explain why the failure of glucocorticoids to adequately manage patients with severe asthma could derive from their inability to affect the immunomodulatory potential of ASM. We will support the view that ASM sensitivity to glucocorticoid therapy can be blunted in severe asthma and will describe some of the factors and mechanisms that could be responsible for glucocorticoid insensitivity.
DOI Link: 10.1111/cea.12577
ISSN: 0954-7894
eISSN: 1365-2222
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2015, Wiley. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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ASM and CS insensitivity (Revised).pdfPost-review (final submitted)207.75 kBAdobe PDFView/Open
Review figures.pptxPost-review (final submitted)136.63 kBUnknownView/Open

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