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dc.contributor.authorMariscalco, Giovanni-
dc.contributor.authorMariani, S.-
dc.contributor.authorBichi, S.-
dc.contributor.authorBiondi, A.-
dc.contributor.authorBlasio, A.-
dc.contributor.authorBorsani, Paolo-
dc.contributor.authorCorti, F.-
dc.contributor.authorDe Chiara, B.-
dc.contributor.authorGherli, Riccardo-
dc.contributor.authorLeva, C.-
dc.contributor.authorRusso, C. F.-
dc.contributor.authorTasca, G.-
dc.contributor.authorVanelli, P.-
dc.contributor.authorAlfieri, O.-
dc.contributor.authorAntona, C.-
dc.contributor.authorDi Credico, G.-
dc.contributor.authorEsposito, G.-
dc.contributor.authorGamba, A.-
dc.contributor.authorMartinelli, L.-
dc.contributor.authorMenicanti, L.-
dc.contributor.authorPaolini, G.-
dc.contributor.authorBeghi, C.-
dc.identifier.citationJournal of Cardiothoracic Surgery, 2015, 10 (1), 169en
dc.description.abstractBACKGROUND: The Trifecta aortic bioprosthesis (St. Jude Medical, Inc., St. Paul, MN, USA) is a stented pericardial heart valve with excellent preliminary results. Aim of the study was to evaluate its early clinical and hemodynamic performances in a multicenter regional registry. METHODS: Between January 2011 and June 2012, 178 consecutive patients undergoing aortic valve replacement with the Trifecta bioprosthesis were prospectively enrolled at 9 Italian centers. Clinical and echocardiographic data were collectedat discharge, 6-months and at 1-year postoperatively. RESULTS: The average age was 75.4 ± 7.7 years,and 95 (53 %) were men. Indication for valve replacement included stenosis in 123 patients (69 %), mixed lesions in 25 (14 %), and regurgitation in 30 (17 %). Ninety-three (52 %) patients were in NYHA functional class III/ IV. Hospital mortality accounted for 5 (2.8 %) patients. No valve-related perioperative complications were encountered. Median follow-up was 20.5 months (range: 1-34). Early (≤6 months) complications included one thromboembolic event, one major bleeding, and 3 endocarditis (2 explants). Two late (>6 months) thromboembolic events and two endocarditis (1 explant) were registered. No valve thrombosis or structural deterioration were observed after discharge. At 30-months, freedom from all-cause mortality was 87 %, freedom from valve-related mortality 99.4 %, freedom from endocarditis 97.5 %, and freedom from valve explants 98 %. At 1-year, mean gradients ranged from 8 to 16 mmHg, and effective orifice area indexes from 1.0 to 1.2 cm(2)/m(2) for valve sizes from 19 to27 mm, respectively. No patients had severe prosthesis-patient mismatch. CONCLUSIONS: Trifecta bioprosthesis provided favourable clinical and hemodynamic results over time.en
dc.publisherBioMed Centralen
dc.rightsCopyright © 2015 Mariscalco et al. Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.en
dc.subjectAortic valve replacementen
dc.subjectHeart valve bioprosthesisen
dc.subjectHeart valve replacementen
dc.titleSt. Jude Medical Trifecta aortic valve: results from a prospective regional multicentre registryen
dc.typeJournal Articleen
dc.description.versionPublisher Versionen
dc.type.subtypeJournal Article-
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicineen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cardiovascular Sciencesen
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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