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Title: Computational modeling of the effects of auditory nerve dysmyelination.
Authors: Brown, A. M.
Hamann, Martine Andree
First Published: 1-Aug-2014
Publisher: Frontiers
Citation: Frontiers in Neuroanatomy, 2014, 8, p. 73
Abstract: Our previous study showed that exposure to loud sound leading to hearing loss elongated the auditory nerve (AN) nodes of Ranvier and triggered notable morphological changes at paranodes and juxtaparanodes. Here we used computational modeling to examine how theoretical redistribution of voltage gated Na(+), Kv3.1, and Kv1.1 channels along the AN may be responsible for the alterations of conduction property following acoustic over-exposure. Our modeling study infers that changes related to Na(+) channel density (rather than the redistribution of voltage gated Na(+), Kv3.1, and Kv1.1 channels) is the likely cause of the decreased conduction velocity and the conduction block observed after acoustic overexposure (AOE).
DOI Link: 10.3389/fnana.2014.00073
eISSN: 1662-5129
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2014 Brown and Hamann. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) ( ). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Appears in Collections:Published Articles, Dept. of Neuroscience, Psychology and Behaviour

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