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|Title:||Tumour Angiogenesis: A Growth Area—From John Hunter to Judah Folkman and Beyond|
|Authors:||Stephenson, J. A.|
Goddard, J. C.
Dennison, A. R.
|Publisher:||Hindawi Publishing Corporation|
|Citation:||Journal of Cancer Research Volume 2013 (2013), Article ID 895019, 6 pages|
|Abstract:||Angiogenesis is the growth of new blood vessels in the body. Abnormal angiogenesis is recognised as a “common denominator” in many disease processes, and the development of angiogenesis inhibitors holds great hope in the ongoing battle against cancer. The field of angiogenesis has roots in the Hunterian era of the late eighteenth century but did not begin to blossom until the early 1970s when the then controversial findings and conclusions of Judah Folkman, the “father of angiogenesis,” were first published. There were only 65 publications with angiogenesis in the title in the 10 years after Folkman first proposed the idea of tumour angiogenesis, compared to over 9,000 publications from the year 2000 to 2010. In this review we will explore the voyage of discovery from the first observations of John Hunter in the eighteenth century, via the struggle faced by Folkman to prove the importance of angiogenesis, and finally how his determination has led to modern angiogenesis inhibitors being used in everyday clinical practice.|
|Rights:||Copyright © 2013 J. A. Stephenson et al. This is an open access article distributed under the Creative Commons Attribution License CC BY 3.0 http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.|
|Appears in Collections:||Published Articles, Dept. of Cancer Studies and Molecular Medicine|
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