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Title: Tumour Angiogenesis: A Growth Area—From John Hunter to Judah Folkman and Beyond
Authors: Stephenson, J. A.
Goddard, J. C.
Al-Taan, O.
Dennison, A. R.
Morgan, B.
First Published: 2013
Publisher: Hindawi Publishing Corporation
Citation: Journal of Cancer Research Volume 2013 (2013), Article ID 895019, 6 pages
Abstract: Angiogenesis is the growth of new blood vessels in the body. Abnormal angiogenesis is recognised as a “common denominator” in many disease processes, and the development of angiogenesis inhibitors holds great hope in the ongoing battle against cancer. The field of angiogenesis has roots in the Hunterian era of the late eighteenth century but did not begin to blossom until the early 1970s when the then controversial findings and conclusions of Judah Folkman, the “father of angiogenesis,” were first published. There were only 65 publications with angiogenesis in the title in the 10 years after Folkman first proposed the idea of tumour angiogenesis, compared to over 9,000 publications from the year 2000 to 2010. In this review we will explore the voyage of discovery from the first observations of John Hunter in the eighteenth century, via the struggle faced by Folkman to prove the importance of angiogenesis, and finally how his determination has led to modern angiogenesis inhibitors being used in everyday clinical practice.
DOI Link: 10.1155/2013/895019
ISSN: 2356-7201
eISSN: 2314-6915
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2013 J. A. Stephenson et al. This is an open access article distributed under the Creative Commons Attribution License CC BY 3.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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