Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/36132
Title: Targeting BCL2-Proteins for the Treatment of Solid Tumours
Authors: Vogler, Meike
First Published: 27-Aug-2014
Publisher: Hindawi Publishing Corporation
Citation: Advances in Medicine Volume 2014 (2014), Article ID 943648, 14 pages
Abstract: Due to their central role in the regulation of apoptosis, the antiapoptotic BCL2-proteins are highly promising targets for the development of novel anticancer treatments. To this end, several strategies have been developed to inhibit BCL2, BCL-XL, BCL-w, and MCL1. While early clinical trials in haematological malignancies demonstrated exciting single-agent activity of BCL2-inhibitors, the response in solid tumours was limited, indicating that, in solid tumours, different strategies have to be developed in order to successfully treat patients with BCL2-inhibitors. In this review, the function of the different antiapoptotic BCL2-proteins and their role in solid tumours will be discussed. In addition, a comprehensive analysis of current small molecules targeting these antiapoptotic BCL2-proteins (e.g., ABT-737, ABT-263, ABT-199, TW-37, sabutoclax, obatoclax, and MIM1) will be provided including a discussion of the results of any clinical trials. This analysis will summarise the potential of BCL2-inhibitors for the treatment of solid tumours and will unravel novel approaches to utilise these inhibitors in clinical applications.
DOI Link: 10.1155/2014/943648
ISSN: 2356-6752
eISSN: 2314-758X
Links: http://www.hindawi.com/journals/amed/2014/943648/
http://hdl.handle.net/2381/36132
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2014 Meike Vogler. This is an open access article distributed under the Creative Commons Attribution License CC BY 3.0 http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:Published Articles, Dept. of Biochemistry

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