Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/36177
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dc.contributor.authorAmelio, I.-
dc.contributor.authorLena, A. M.-
dc.contributor.authorBonanno, E.-
dc.contributor.authorMelino, G.-
dc.contributor.authorCandi, E.-
dc.date.accessioned2016-01-06T10:42:17Z-
dc.date.available2016-01-06T10:42:17Z-
dc.date.issued2013-11-14-
dc.identifier.citationCell Death and Disease (2013) 4, e922en
dc.identifier.issn2041-4889-
dc.identifier.urihttp://www.nature.com/cddis/journal/v4/n11/full/cddis2013426a.htmlen
dc.identifier.urihttp://hdl.handle.net/2381/36177-
dc.description.abstractDuring embryonic development, hair follicles (HFs) develop from an epidermal–mesenchymal cross talk between the ectoderm progenitor layer and the underlying dermis. Epidermal stem cell activation represents a crucial point both for HF morphogenesis and for hair regeneration. miR-24 is an anti-proliferative microRNA (miRNA), which is induced during differentiation of several cellular systems including the epidermis. Here, we show that miR-24 is expressed in the HF and has a role in hair morphogenesis. We generated transgenic mice ectopically expressing miR-24 under the K5 promoter. The K5::miR-24 animals display a marked defect in HF morphogenesis, with thinning of hair coat and altered HF structure. Expression of miR-24 alters the normal process of hair keratinocyte differentiation, leading to altered expression of differentiation markers. MiR-24 directly represses the hair keratinocyte stemness regulator Tcf-3. These results support the notion that microRNAs, and among them miR-24, have an important role in postnatal epidermal homeostasis.en
dc.language.isoenen
dc.publisherNature Publishing Group for Associazione Differenziamento e Morte Cellulareen
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/.en
dc.subjectmicroRNAen
dc.subjectmiR-24en
dc.subjecthair follicleen
dc.subjectskinen
dc.subjectTcf-3en
dc.subjectstem cellsen
dc.titlemiR-24 affects hair follicle morphogenesis targeting Tcf-3en
dc.typeJournal Articleen
dc.identifier.doi10.1038/cddis.2013.426-
dc.identifier.eissn2041-4889-
dc.description.statusPeer-revieweden
dc.description.versionPublisher Versionen
dc.dateaccepted2013-09-30-
Appears in Collections:Published Articles, MRC Toxicology Unit

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