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dc.contributor.authorAmelio, I.-
dc.contributor.authorLena, A. M.-
dc.contributor.authorBonanno, E.-
dc.contributor.authorMelino, G.-
dc.contributor.authorCandi, E.-
dc.identifier.citationCell Death and Disease (2013) 4, e922en
dc.description.abstractDuring embryonic development, hair follicles (HFs) develop from an epidermal–mesenchymal cross talk between the ectoderm progenitor layer and the underlying dermis. Epidermal stem cell activation represents a crucial point both for HF morphogenesis and for hair regeneration. miR-24 is an anti-proliferative microRNA (miRNA), which is induced during differentiation of several cellular systems including the epidermis. Here, we show that miR-24 is expressed in the HF and has a role in hair morphogenesis. We generated transgenic mice ectopically expressing miR-24 under the K5 promoter. The K5::miR-24 animals display a marked defect in HF morphogenesis, with thinning of hair coat and altered HF structure. Expression of miR-24 alters the normal process of hair keratinocyte differentiation, leading to altered expression of differentiation markers. MiR-24 directly represses the hair keratinocyte stemness regulator Tcf-3. These results support the notion that microRNAs, and among them miR-24, have an important role in postnatal epidermal homeostasis.en
dc.publisherNature Publishing Group for Associazione Differenziamento e Morte Cellulareen
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit
dc.subjecthair follicleen
dc.subjectstem cellsen
dc.titlemiR-24 affects hair follicle morphogenesis targeting Tcf-3en
dc.typeJournal Articleen
dc.description.versionPublisher Versionen
Appears in Collections:Published Articles, MRC Toxicology Unit

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