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Title: Bedside assessment of quadriceps muscle by ultrasound after admission for acute exacerbations of chronic respiratory disease
Authors: Greening, Neil J.
Harvey-Dunstan, T. C.
Chaplin, E. J.
Vincent, E. E.
Morgan, M. D.
Singh, S. J.
Steiner, M. C.
First Published: 1-Oct-2015
Publisher: American Thoracic Society
Citation: American Journal of Respiratory and Critical Care Medicine, 2015, 192 (7), pp. 810-816
Abstract: RATIONALE: Hospitalization represents a major event for the patient with chronic respiratory disease. There is a high risk of readmission, which over the longer term may be related more closely to the underlying condition of the patient, such as skeletal muscle dysfunction. OBJECTIVES: We assessed the risk of hospital readmission at 1 year, including measures of lower limb muscle as part of a larger clinical trial. METHODS: Patients hospitalized with an exacerbation of chronic respiratory disease underwent measures of muscle function including quadriceps ultrasound. Independent factors influencing time to hospital readmission or death were identified. Patients were classified into four quartiles based on quadriceps size and compared. MEASUREMENTS AND MAIN RESULTS: One hundred and ninety-one patients (mean age, 71.6 [SD, 9.1] yr) were recruited. One hundred and thirty (68%) were either readmitted or died. Factors associated with readmission or death were age (odds ratio [OR], 1.05; 95% confidence interval [CI], 1.01-1.08; P = 0.015), Medical Research Council (MRC) dyspnea grade (OR, 4.57; 95% CI, 2.62-7.95; P < 0.001), home oxygen use (OR, 12.4; 95% CI, 4.53-33.77; P < 0.001), quadriceps (rectus femoris) cross-sectional area (Qcsa) (OR, 0.34; 95% CI, 0.17-0.65; P = 0.001), and hospitalization in the previous year (OR, 4.82; 95% CI, 2.42-9.58; P < 0.001). In the multivariate analyses, home oxygen use (OR, 4.80; 95% CI, 1.68-13.69; P = 0.003), MRC dyspnea grade (OR, 2.57; 95% CI, 1.44-4.59; P = 0.001), Qcsa (OR, 0.46; 95% CI, 0.22-0.95; P = 0.035), and previous hospitalization (OR, 3.04; 95% CI, 1.47-6.29; P = 0.003) were independently associated with readmission or death. Patients with the smallest muscle spent more days in hospital than those with largest muscle (28.1 [SD, 33.9] vs. 12.2 [SD, 23.5] d; P = 0.007). CONCLUSIONS: Smaller quadriceps muscle size, as measured by ultrasound in the acute care setting, is an independent risk factor for unscheduled readmission or death, which may have value both in clinical practice and for risk stratification.
DOI Link: 10.1164/rccm.201503-0535OC
ISSN: 1073-449X
eISSN: 1535-4970
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2015 by the American Thoracic Society. Originally Published in: Neil J. Greening, Theresa C. Harvey-Dunstan, Emma J. Chaplin, Emma E. Vincent, Mike D. Morgan, Sally J. Singh, and Michael C. Steiner "Bedside Assessment of Quadriceps Muscle by Ultrasound after Admission for Acute Exacerbations of Chronic Respiratory Disease", American Journal of Respiratory and Critical Care Medicine, Vol. 192, No. 7 (2015), pp. 810-816. The final publication is available at
Description: Archived on publication with reference to the Publisher's Access Policies, available at
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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