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Title: Small lipidated anti-obesity compounds derived from neuromedin U
Authors: Micewicz, E. D.
Bahattab, O. S.
Willars, Gary Brian
Waring, A. J.
Navab, M.
Whitelegge, J. P.
McBride, W. H.
Ruchala, P.
First Published: 14-Jul-2015
Publisher: Elsevier, French Société de Chimie Thérapeutique (SCT)
Citation: European Journal of Medicinal Chemistry, 2015, 101, pp. 616-626
Abstract: A small library of truncated/lipid-conjugated neuromedin U (NmU) analogs was synthesized and tested in vitro using an intracellular calcium signaling assay. The selected, most active analogs were then tested in vivo, and showed potent anorexigenic effects in a diet-induced obese (DIO) mouse model. The most promising compound, NM4-C16 was effective in a once-weekly-dose regimen. Collectively, our findings suggest that short, lipidated analogs of NmU are suitable leads for the development of novel anti-obesity therapeutics.
DOI Link: 10.1016/j.ejmech.2015.07.020
ISSN: 0223-5234
eISSN: 1768-3254
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2015, Elsevier Masson SAS. All rights reserved. This manuscript version is made available after the end of the embargo period under the CC-BY-NC-ND 4.0 license 
Description: The file associated with this record is under a 24-month embargo from publication in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, College of Medicine, Biological Sciences and Psychology

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