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|Title:||[Ca2+]i oscillations in ASM: relationship with persistent airflow obstruction in asthma.|
Saunders, Ruth Mary
Challiss, R.A. John
Brightling, Christopher E.
|Publisher:||Wiley for Asian Pacific Society of Respirology|
|Citation:||Respirology, 2014, 19 (5), pp. 763-766|
|Abstract:||The cause of airway smooth muscle (ASM) hypercontractility in asthma is not fully understood. The relationship of spontaneous intracellular calcium oscillation frequency in ASM to asthma severity was investigated. Oscillations were increased in subjects with impaired lung function abolished by extracellular calcium removal, attenuated by caffeine and unaffected by verapamil or nitrendipine. Whether modulation of increased spontaneous intracellular calcium oscillations in ASM from patients with impaired lung function represents a therapeutic target warrants further investigation.|
|Rights:||Copyright © 2014 The Authors. Respirology published by Wiley Publishing Asia Pty Ltd on behalf of Asian Pacific Society of Respirology. This is an open access article under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0/ ), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.|
|Appears in Collections:||Published Articles, Dept. of Infection, Immunity and Inflammation|
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