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Title: [Ca2+]i oscillations in ASM: relationship with persistent airflow obstruction in asthma.
Authors: Sweeney, David
Hollins, Fay
Gomez, Edith
Saunders, Ruth Mary
Challiss, R.A. John
Brightling, Christopher E.
First Published: 22-May-2014
Publisher: Wiley for Asian Pacific Society of Respirology
Citation: Respirology, 2014, 19 (5), pp. 763-766
Abstract: The cause of airway smooth muscle (ASM) hypercontractility in asthma is not fully understood. The relationship of spontaneous intracellular calcium oscillation frequency in ASM to asthma severity was investigated. Oscillations were increased in subjects with impaired lung function abolished by extracellular calcium removal, attenuated by caffeine and unaffected by verapamil or nitrendipine. Whether modulation of increased spontaneous intracellular calcium oscillations in ASM from patients with impaired lung function represents a therapeutic target warrants further investigation.
DOI Link: 10.1111/resp.12318
ISSN: 1323-7799
eISSN: 1440-1843
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2014 The Authors. Respirology published by Wiley Publishing Asia Pty Ltd on behalf of Asian Pacific Society of Respirology. This is an open access article under the terms of the Creative Commons Attribution License ( ), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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