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Title: RIPOSTE: a framework for improving the design and analysis of laboratory-based research
Authors: Masca, Nicholas
Hensor, E. M.
Cornelius, V. R.
Buffa, F. M.
Marriott, H. M.
Eales, J. M.
Messenger, M. P.
Anderson, A. E.
Boot, C.
Bunce, C.
Goldin, R. D.
Harris, J.
Hinchliffe, R. F.
Junaid, H.
Kingston, S.
Martin-Ruiz, C.
Nelson, Christopher Paul
Peacock, J.
Seed, P. T.
Shinkins, B.
Staples, K. J.
Toombs, J.
Wright, Adam K. A.
Teare, M. D.
First Published: 7-Mar-2015
Publisher: eLife Sciences Publications
Citation: Elife, 2015, 4 : e05519
Abstract: Lack of reproducibility is an ongoing problem in some areas of the biomedical sciences. Poor experimental design and a failure to engage with experienced statisticians at key stages in the design and analysis of experiments are two factors that contribute to this problem. The RIPOSTE (Reducing IrreProducibility in labOratory STudiEs) framework has been developed to support early and regular discussions between scientists and statisticians in order to improve the design, conduct and analysis of laboratory studies and, therefore, to reduce irreproducibility. This framework is intended for use during the early stages of a research project, when specific questions or hypotheses are proposed. The essential points within the framework are explained and illustrated using three examples (a medical equipment test, a macrophage study and a gene expression study). Sound study design minimises the possibility of bias being introduced into experiments and leads to higher quality research with more reproducible results.
DOI Link: 10.7554/eLife.05519
eISSN: 2050-084X
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2015, Masca et al. This article is distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use and redistribution provided that the original author and source are credited. - See more at:
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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