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|Title:||Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection|
|Authors:||Khader, S. A.|
Jelley-Gibbs, D. M.
Pearl, John Edward
Desauvage, F. J.
Lund, F. E.
Cooper, A. M.
|Publisher:||Rockefeller University Press|
|Citation:||Journal of Experimental Medicine, 2006, 203 (7), pp. 1805-1815|
|Abstract:||Migration of dendritic cells (DCs) to the draining lymph node (DLN) is required for the activation of naive T cells. We show here that migration of DCs from the lung to the DLN after Mycobacterium tuberculosis (Mtb) exposure is defective in mice lacking interleukin (IL)-12p40. This defect compromises the ability of IL-12p40-deficient DCs to activate naive T cells in vivo; however, DCs that express IL-12p40 alone can activate naive T cells. Treatment of IL-12p40-deficient DCs with IL-12p40 homodimer (IL-12(p40)(2)) restores Mtb-induced DC migration and the ability of IL-12p40-deficient DCs to activate naive T cells. These data define a novel and fundamental role for IL-12p40 in the pathogen-induced activation of pulmonary DCs.|
|Rights:||Copyright © The Rockefeller University Press, 2006. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.|
|Appears in Collections:||Published Articles, Dept. of Infection, Immunity and Inflammation|
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