Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/36339
Title: Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection
Authors: Khader, S. A.
Partida-Sanchez, S.
Bell, G.
Jelley-Gibbs, D. M.
Swain, S.
Pearl, John Edward
Ghilardi, N.
Desauvage, F. J.
Lund, F. E.
Cooper, A. M.
First Published: 10-Jul-2006
Publisher: Rockefeller University Press
Citation: Journal of Experimental Medicine, 2006, 203 (7), pp. 1805-1815
Abstract: Migration of dendritic cells (DCs) to the draining lymph node (DLN) is required for the activation of naive T cells. We show here that migration of DCs from the lung to the DLN after Mycobacterium tuberculosis (Mtb) exposure is defective in mice lacking interleukin (IL)-12p40. This defect compromises the ability of IL-12p40-deficient DCs to activate naive T cells in vivo; however, DCs that express IL-12p40 alone can activate naive T cells. Treatment of IL-12p40-deficient DCs with IL-12p40 homodimer (IL-12(p40)(2)) restores Mtb-induced DC migration and the ability of IL-12p40-deficient DCs to activate naive T cells. These data define a novel and fundamental role for IL-12p40 in the pathogen-induced activation of pulmonary DCs.
DOI Link: 10.1084/jem.20052545
ISSN: 0022-1007
eISSN: 1540-9538
Links: http://jem.rupress.org/content/203/7/1805
http://hdl.handle.net/2381/36339
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © The Rockefeller University Press, 2006. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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