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Title: Human Metapneumovirus as a Cause of Community-Acquired Respiratory Illness
Authors: Stockton, J.
Stephenson, Iain
Fleming, D.
Zambon, M.
First Published: Sep-2002
Publisher: Centers for Disease Control and Prevention
Citation: Emerging Infectious Diseases 2002 Sep; 8(9): 897–901.
Abstract: Human metapneumovirus (HMPV) is a recently identified Paramyxovirus first isolated from hospitalized children with acute respiratory tract infections (ARTI). We sought evidence of HMPV infection in patients who had visited general practitioners, had influenzalike illnesses (ILI), and had negative tests for influenza and Human respiratory syncytial virus (HRSV). As part of national virologic surveillance, sentinel general practices in England and Wales collected samples from patients of all ages with ILI during winter 2000–01. Reverse transcriptase-polymerase chain reaction (PCR) for HMPV, influenza A (H1 and H3), influenza B, and HRSV was used to screen combined nose and throat swabs. PCR products from the HMPV-positive samples were sequenced to confirm identity and construct phylogenetic trees. Of 711 swabs submitted, 408 (57.3%) were negative for influenza and HRSV; HMPV was identified in 9 (2.2%) patients. HMPV appears to be associated with community-acquired ARTI. The extent of illness and possible complications related to this new human virus need to be clarified.
DOI Link: 10.3201/eid0809.020084
ISSN: 1080-6040
eISSN: 1080-6059
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Articles published in this U.S. Government publication journals are in the public domain and may be used and reproduced without special permission. However, anyone using the material is requested to properly cite and acknowledge the source.
Description: PMCID: PMC2732534 The sequence information generated from this study is deposited in EMBL under accession numbers AJ420267–AJ420273.
Appears in Collections:Published Articles, College of Medicine, Biological Sciences and Psychology

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