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|Title:||Airway eosinophils in older teenagers with outgrown preschool wheeze: a pilot study.|
Beardsmore, Caroline S.
Pescatore, Anina M.
Kuehni, Claudia E.
Gaillard, Erol A.
|Publisher:||European Respiratory Society|
|Citation:||European Respiratory Journal, 2015, 46 (5), pp. 1486-1489|
|Abstract:||Preschool wheezing affects one-third of all children growing up in the UK . It varies in clinical presentation and severity, and there is evidence to suggest the co-existence of different wheeze phenotypes , some of which have been associated with adult asthma and chronic obstructive pulmonary disease . Using data from the Leicester Respiratory Cohort studies , we have previously applied objective data-driven methods to distinguish three distinct preschool wheeze phenotypes: “atopic” and “non-atopic” persistent wheeze (PW) and transient viral wheeze (TVW) . In children with PW, attacks of wheeze with and without colds were observed both at preschool age (0–5 years) and when followed-up at early school-age (4–8 years). Children with TVW, triggered predominantly by colds, had symptoms at age 0–5 years but not at age 4–8 years. Prognosis 5 years later (aged 8–13 years) was markedly better in children with TVW compared to the two PW phenotypes .|
|Rights:||Copyright © 2015, European Respiratory Society. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website. following the embargo period the version associated with this record is distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ ), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.|
|Appears in Collections:||Published Articles, College of Medicine, Biological Sciences and Psychology|
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