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Title: Airway eosinophils in older teenagers with outgrown preschool wheeze: a pilot study.
Authors: Marshall, Lucy
Beardsmore, Caroline S.
Pescatore, Anina M.
Kuehni, Claudia E.
Gaillard, Erol A.
First Published: 1-Nov-2015
Publisher: European Respiratory Society
Citation: European Respiratory Journal, 2015, 46 (5), pp. 1486-1489
Abstract: Preschool wheezing affects one-third of all children growing up in the UK [1]. It varies in clinical presentation and severity, and there is evidence to suggest the co-existence of different wheeze phenotypes [2], some of which have been associated with adult asthma and chronic obstructive pulmonary disease [3]. Using data from the Leicester Respiratory Cohort studies [4], we have previously applied objective data-driven methods to distinguish three distinct preschool wheeze phenotypes: “atopic” and “non-atopic” persistent wheeze (PW) and transient viral wheeze (TVW) [5]. In children with PW, attacks of wheeze with and without colds were observed both at preschool age (0–5 years) and when followed-up at early school-age (4–8 years). Children with TVW, triggered predominantly by colds, had symptoms at age 0–5 years but not at age 4–8 years. Prognosis 5 years later (aged 8–13 years) was markedly better in children with TVW compared to the two PW phenotypes [6].
DOI Link: 10.1183/13993003.00174-2015
ISSN: 0903-1936
eISSN: 1399-3003
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2015, European Respiratory Society. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website. following the embargo period the version associated with this record is distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License ( ), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Appears in Collections:Published Articles, College of Medicine, Biological Sciences and Psychology

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