Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/36449
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dc.contributor.authorSiddiqui, S.-
dc.contributor.authorCruse, G.-
dc.contributor.authorMcKenna, S.-
dc.contributor.authorMonteiro, W.-
dc.contributor.authorMistry, V.-
dc.contributor.authorWardlaw, A.-
dc.contributor.authorBrightling, Christopher Edward-
dc.date.accessioned2016-01-28T12:04:43Z-
dc.date.available2016-01-28T12:04:43Z-
dc.date.issued2009-07-14-
dc.identifier.citationBMC Pulmonary Medicine, 2009, 9 : 34en
dc.identifier.urihttp://bmcpulmmed.biomedcentral.com/articles/10.1186/1471-2466-9-34en
dc.identifier.urihttp://hdl.handle.net/2381/36449-
dc.description.abstractBACKGROUND: In asthma interleukin (IL)-13 is increased in the airway compared with non-asthmatic eosinophilic bronchitis. Whether this differential expression is specific to the airway or is more generalised is uncertain. METHODS: We sought to examine IL-13 expression in peripheral blood T-cells and eosinophils in asthma and non-asthmatic eosinophilic bronchitis. Peripheral blood CD3+ cell and eosinophil intracellular IL-13 expression from subjects with asthma, non-asthmatic eosinophilic bronchitis and healthy controls was assessed. The effect of priming by asthmatic serum on the release of IL-13 by peripheral blood mononuclear cells from healthy subjects was examined and the serum from these subjects was analysed for a range of chemokines and cytokines. RESULTS: The median (IQR)% intracellular IL-13 expression by CD3+ cells was increased in asthma [5.3 (2.7-9.8)%; n = 12] compared to non-asthmatic eosinophilic bronchitis [1.1 (0.5-3)%; n = 7] and healthy controls [1.7 (0.2-3%); n = 9] (p = 0.02), but was not significantly different in eosinophils across the groups. IL-13 released from healthy peripheral blood mononuclear cells (n = 10) was increased by asthmatic serum [117 (47.8-198)pg/ml] compared to control [78.5 (42.6-128)pg/ml; p = 0.02), but was not affected by non-asthmatic serum. CONCLUSION: Our findings support the view that IL-13 expression is increased in peripheral blood-derived T cells in asthma and that asthmatic serum up-regulates IL-13 release from healthy peripheral blood mononuclear cells.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/19602238-
dc.rightsCopyright © 2009 Siddiqui et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons. org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectAdulten
dc.subjectAsthmaen
dc.subjectBronchitisen
dc.subjectCase-Control Studiesen
dc.subjectEosinophilsen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectInterleukin-13en
dc.subjectLeukocytes, Mononuclearen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectT-Lymphocytesen
dc.subjectUp-Regulationen
dc.titleIL-13 expression by blood T cells and not eosinophils is increased in asthma compared to non-asthmatic eosinophilic bronchitis.en
dc.typeJournal Articleen
dc.identifier.doi10.1186/1471-2466-9-34-
dc.identifier.eissn1471-2466-
dc.identifier.pii1471-2466-9-34-
dc.description.statusPeer-revieweden
dc.description.versionPublisher Versionen
dc.type.subtypeJournal Article;Research Support, Non-U.S. Gov't-
pubs.organisational-group/Organisationen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGYen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicineen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and Inflammationen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Molecular & Cellular Bioscienceen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Respiratory Scienceen
dc.dateaccepted2009-07-14-
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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