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Title: Fighting against kidney diseases with small interfering RNA: opportunities and challenges
Authors: Yang, C.
Zhang, C.
Zhao, Z.
Zhu, T.
Yang, Bin
First Published: 1-Feb-2015
Publisher: BioMed Central
Citation: Journal of Translational Medicine, 2015, 13 : 39
Abstract: The significant improvements in siRNA therapy have been achieved, which have great potential applications in humans. The kidney is a comparatively easy target organ of siRNA therapy due to its unique structural and functional characteristics. Here, we reviewed recent achievements in siRNA design, delivery and application with focuses on kidney diseases, in particular kidney transplant-related injuries. In addition, the strategy for increasing serum stability and immune tolerance of siRNA was also discussed. At last, the future challenges of siRNA therapy including organ/tissue/cell-specific delivery and time-controlled silence, as well as selecting therapeutic targets, were addressed as well.
DOI Link: 10.1186/s12967-015-0387-2
eISSN: 1479-5876
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © Yang et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://​creativecommons.​org/​licenses/​by/​4.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://​creativecommons.​org/​publicdomain/​zero/​1.​0/​) applies to the data made available in this article, unless otherwise stated.
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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