Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/36565
Title: Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis
Authors: Ricci, S.
Grandgirard, D.
Wenzel, M.
Braccini, T.
Salvatore, P.
Oggioni, Marco Rinaldo
Leib, S. L.
Koedel, U.
First Published: 31-Dec-2014
Publisher: BioMed Central Ltd
Citation: BMC Infectious Diseases, 2014, 14, 726
Abstract: Background: Approximately 7% of survivors from meningococcal meningitis (MM) suffer from neurological sequelae due to brain damage in the course of meningitis. The present study focuses on the role of matrix metalloproteinases (MMPs) in a novel mouse model of MM-induced brain damage. Methods: The model is based on intracisternal infection of BALB/c mice with a serogroup C Neisseria meningitidis strain. Mice were infected with meningococci and randomised for treatment with the MMP inhibitor batimastat (BB-94) or vehicle. Animal survival, brain injury and host-response biomarkers were assessed 48 h after meningococcal challenge. Results: Mice that received BB-94 presented significantly diminished MMP-9 levels (p < 0.01), intracerebral bleeding (p < 0.01), and blood-brain barrier (BBB) breakdown (p < 0.05) in comparison with untreated animals. In mice suffering from MM, the amount of MMP-9 measured by zymography significantly correlated with both intracerebral haemorrhage (p < 0.01) and BBB disruption (p < 0.05). Conclusions: MMPs significantly contribute to brain damage associated with experimental MM. Inhibition of MMPs reduces intracranial complications in mice suffering from MM, representing a potential adjuvant strategy in MM post-infection sequelae.
DOI Link: 10.1186/s12879-014-0726-6
ISSN: 1471-2334
Links: http://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-014-0726-6
http://hdl.handle.net/2381/36565
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2014 Ricci et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Appears in Collections:Published Articles, Dept. of Genetics

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