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|Title:||Physiological state gates acquisition and expression of mesolimbic reward prediction signals|
|Authors:||Cone, J. J.|
Fortin, S. M.
Stuber, G. D.
McCutcheon, James E.
Roitman, M. F.
|Publisher:||National Academy of Sciences|
|Citation:||Proceedings of the National Academy of Sciences of USA, 2016, 113(7), pp. 1943-1948|
|Abstract:||Phasic dopamine signaling participates in associative learning by reinforcing associations between outcomes (unconditioned stimulus; US) and their predictors (conditioned stimulus; CS). However, prior work has always engendered these associations with innately rewarding stimuli. Thus, whether dopamine neurons can acquire prediction signals in the absence of appetitive experience and update them when the value of the outcome changes remains unknown. Here, we used sodium depletion to reversibly manipulate the appetitive value of a hypertonic sodium solution while measuring phasic dopamine signaling in rat nucleus accumbens. Dopamine responses to the NaCl US following sodium depletion updated independent of prior experience. In contrast, prediction signals were only acquired through extensive experience with a US that had positive affective value. Once learned, dopamine prediction signals were flexibly expressed in a state-dependent manner. Our results reveal striking differences with respect to how physiological state shapes dopamine signals evoked by outcomes and their predictors.|
|Rights:||Copyright © 2016, the authors. Exclusive Licensee: PNAS. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.|
|Description:||The file associated with this record is under a permanent embargo while publication is In Press in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.|
|Appears in Collections:||Published Articles, Dept. of Neuroscience, Psychology and Behaviour|
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|Cone et al main text.docx||Post-review (final submitted)||114.37 kB||Unknown||View/Open|
|Cone et al main text.pdf||Post-review (final submitted)||274.45 kB||Adobe PDF||View/Open|
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