Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/36572
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dc.contributor.authorCone, J. J.-
dc.contributor.authorFortin, S. M.-
dc.contributor.authorMcHenry, J.-
dc.contributor.authorStuber, G. D.-
dc.contributor.authorMcCutcheon, James E.-
dc.contributor.authorRoitman, M. F.-
dc.date.accessioned2016-02-04T12:12:30Z-
dc.date.available2016-03-09T02:45:09Z-
dc.date.issued2016-02-16-
dc.identifier.citationProceedings of the National Academy of Sciences of USA, 2016, 113(7), pp. 1943-1948en
dc.identifier.issn1091-6490-
dc.identifier.urihttp://www.pnas.org/content/113/7/1943.shorten
dc.identifier.urihttp://hdl.handle.net/2381/36572-
dc.descriptionThe file associated with this record is under a permanent embargo while publication is In Press in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.en
dc.description.abstractPhasic dopamine signaling participates in associative learning by reinforcing associations between outcomes (unconditioned stimulus; US) and their predictors (conditioned stimulus; CS). However, prior work has always engendered these associations with innately rewarding stimuli. Thus, whether dopamine neurons can acquire prediction signals in the absence of appetitive experience and update them when the value of the outcome changes remains unknown. Here, we used sodium depletion to reversibly manipulate the appetitive value of a hypertonic sodium solution while measuring phasic dopamine signaling in rat nucleus accumbens. Dopamine responses to the NaCl US following sodium depletion updated independent of prior experience. In contrast, prediction signals were only acquired through extensive experience with a US that had positive affective value. Once learned, dopamine prediction signals were flexibly expressed in a state-dependent manner. Our results reveal striking differences with respect to how physiological state shapes dopamine signals evoked by outcomes and their predictors.en
dc.language.isoenen
dc.publisherNational Academy of Sciencesen
dc.rightsCopyright © 2016, the authors. Exclusive Licensee: PNAS. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.en
dc.subjectNucleus Accumbensen
dc.subjectDopamineen
dc.subjectVoltammetryen
dc.subjectLearningen
dc.subjectMotivationen
dc.titlePhysiological state gates acquisition and expression of mesolimbic reward prediction signalsen
dc.typeJournal Articleen
dc.identifier.doi10.1073/pnas.1519643113-
dc.description.statusPeer-revieweden
dc.description.versionPost-printen
dc.type.subtypeArticle-
pubs.organisational-group/Organisationen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGYen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departmentsen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departments/Neuroscience, Psychology and Behaviouren
dc.dateaccepted2016-01-08-
Appears in Collections:Published Articles, Dept. of Neuroscience, Psychology and Behaviour

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