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Title: Measuring pressure during coronary artery angiography in ex-vivo Hearts
Authors: Robinson, Claire
Adnan, Asif K.
Adlam, David
Biggs, Mike
Rutty, Guy Nathan
Morgan, Bruno
First Published: 12-Nov-2015
Publisher: Elsevier
Citation: Journal of Forensic Radiology and Imaging, 2016, 4, pp. 58-62
Abstract: Coronary artery disease (CAD) is the most common cause of sudden adult death. Diagnosis in life and after death is therefore crucial, but can be problematic and inaccurate. Post-mortem CT angiography (PMCTA) is attempting to address this, but its accuracy is still not fully established. In clinical practice, pressure measurements, recording drops in pressure across the stenosis, are now being used to determine physiological significance, as the degree of narrowing on imaging can be misleading. This study was designed to investigate the introduction of pressure measurement to PMCTA in order to understand the importance of re-pressurising vessels in the evaluation of CAD. Ex-vivo porcine hearts were used to develop the technique. Methods to introduce catheters and wires were investigated and a system was developed to suspend the heart, to enable pressure tests and CT scans. Consistent measurable pressures were achieved with good correlation of measured arterial pressure to delivered pressure in most cases. Pressure measurements were shown to be inaccurate in decomposed hearts, poor dissection and cannulation damaging the vessel, contamination of the vessels (e.g. by air) and malposition of the pressure measurement wire.
DOI Link: 10.1016/j.jofri.2015.11.005
ISSN: 2212-4780
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2015 Elsevier Ltd. All rights reserved. This manuscript version is made available after the end of the embargo period under the CC-BY-NC-ND 4.0 license 
Description: The file associated with this record is under a 12-month embargo from publication in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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