Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/36595
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dc.contributor.authorHenson, Joseph-
dc.contributor.authorDavies, Melanie J.-
dc.contributor.authorBodicoat, Danielle H.-
dc.contributor.authorEdwardson, Charlotte L.-
dc.contributor.authorGill, J. M.-
dc.contributor.authorStensel, D. J.-
dc.contributor.authorTolfrey, K.-
dc.contributor.authorDunstan, D. W.-
dc.contributor.authorKhunti, Kamlesh-
dc.contributor.authorYates, Thomas-
dc.date.accessioned2016-02-08T11:33:05Z-
dc.date.available2016-02-08T11:33:05Z-
dc.date.issued2015-12-01-
dc.identifier.citationDiabetes Care, 2016, 39 (1), pp. 130-138en
dc.identifier.urihttp://care.diabetesjournals.org/content/39/1/130en
dc.identifier.urihttp://hdl.handle.net/2381/36595-
dc.description.abstractOBJECTIVE: To determine whether breaking up prolonged sitting with short bouts of standing or walking improves postprandial markers of cardiometabolic health in women at high risk of type 2 diabetes. RESEARCH DESIGN AND METHODS: Twenty-two overweight/obese, dysglycemic, postmenopausal women (mean ± SD age 66.6 ± 4.7 years) each participated in two of the following treatments: prolonged, unbroken sitting (7.5 h) or prolonged sitting broken up with either standing or walking at a self-perceived light intensity (for 5 min every 30 min). Both allocation and treatment order were randomized. The incremental area under the curves (iAUCs) for glucose, insulin, nonesterified fatty acids (NEFA), and triglycerides were calculated for each treatment condition (mean ± SEM). The following day, all participants underwent the 7.5-h sitting protocol. RESULTS: Compared with a prolonged bout of sitting (iAUC 5.3 ± 0.8 mmol/L ⋅ h), both standing (3.5 ± 0.8 mmol/L ⋅ h) and walking (3.8 ± 0.7 mmol/L ⋅ h) significantly reduced the glucose iAUC (both P < 0.05). When compared with prolonged sitting (548.2 ± 71.8 mU/L ⋅ h), insulin was also reduced for both activity conditions (standing, 437.2 ± 73.5 mU/L ⋅ h; walking, 347.9 ± 78.7 mU/L ⋅ h; both P < 0.05). Both standing (-1.0 ± 0.2 mmol/L ⋅ h) and walking (-0.8 ± 0.2 mmol/L ⋅ h) attenuated the suppression of NEFA compared with prolonged sitting (-1.5 ± 0.2 mmol/L ⋅ h) (both P < 0.05). There was no significant effect on triglyceride iAUC. The effects on glucose (standing and walking) and insulin (walking only) persisted into the following day. CONCLUSIONS: Breaking up prolonged sitting with 5-min bouts of standing or walking at a self-perceived light intensity reduced postprandial glucose, insulin, and NEFA responses in women at high risk of type 2 diabetes. This simple, behavioral approach could inform future public health interventions aimed at improving the metabolic profile of postmenopausal, dysglycemic women.en
dc.language.isoenen
dc.publisherAmerican Diabetes Associationen
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/26628415-
dc.rightsCopyright © 2016 by the American Diabetes Association. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website. This is an author-created, uncopyedited electronic version of an article accepted for publication in Diabetes. The American Diabetes Association (ADA), publisher of Diabetes, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version will be available in a future issue of Diabetes in print and online at http://care.diabetesjournals.org/content/39/1/130en
dc.titleBreaking Up Prolonged Sitting With Standing or Walking Attenuates the Postprandial Metabolic Response in Postmenopausal Women: A Randomized Acute Studyen
dc.typeJournal Articleen
dc.identifier.doi10.2337/dc15-1240-
dc.identifier.eissn1935-5548-
dc.identifier.piidc15-1240-
dc.description.statusPeer-revieweden
dc.description.versionPost-printen
dc.type.subtypeJournal Article-
pubs.organisational-group/Organisationen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGYen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicineen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cardiovascular Sciencesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Health Sciencesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Cardiovascularen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Populationen
dc.dateaccepted2015-10-08-
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences



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