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Title: Review: Modulating the unfolded protein response to prevent neurodegeneration and enhance memory
Authors: Halliday, Mark
Mallucci, Giovanna R.
First Published: 13-May-2015
Publisher: Wiley for British Neuropathological Society
Citation: Neuropathology and Applied Neurobiology 2015; 41: 414–427
Abstract: Recent evidence has placed the unfolded protein response (UPR) at the centre of pathological processes leading to neurodegenerative disease. The translational repression caused by UPR activation starves neurons of the essential proteins they need to function and survive. Restoration of protein synthesis, via genetic or pharmacological means, is neuroprotective in animal models, prolonging survival. This is of great interest due to the observation of UPR activation in the post mortem brains of patients with Alzheimer's, Parkinson's, tauopathies and prion diseases. Protein synthesis is also an essential step in the formation of new memories. Restoring translation in disease or increasing protein synthesis from basal levels has been shown to improve memory in numerous models. As neurodegenerative diseases often present with memory impairments, targeting the UPR to both provide neuroprotection and enhance memory provides an extremely exciting novel therapeutic target.
DOI Link: 10.1111/nan.12211
ISSN: 0305-1846
eISSN: 1365-2990
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: © 2014 The Authors. Neuropathology and Applied Neurobiology published by John Wiley & Sons Ltd on behalf of British Neuropathological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:Published Articles, MRC Toxicology Unit

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