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dc.contributor.authorCandi, E.-
dc.contributor.authorAmelio, I.-
dc.contributor.authorAgostini, M.-
dc.contributor.authorMelino, G.-
dc.identifier.citationCell Death and Differentiation (2015) 22, 12–21en
dc.description.abstractMicroRNAs (miRs) are a class of small noncoding RNAs that suppress the expression of protein-coding genes by repressing protein translation. Although the roles that miRs and the miR processing machinery have in regulating epithelial stem cell biology are not fully understood, their fundamental contributions to these processes have been demonstrated over the last few years. The p53-family member p63 is an essential transcription factor for epidermal morphogenesis and homeostasis. p63 functions as a determinant for keratinocyte cell fate and helps to regulate the balance between stemness, differentiation and senescence. An important factor that regulates p63 function is the reciprocal interaction between p63 and miRs. Some miRs control p63 expression, and p63 regulates the miR expression profile in the epidermis. p63 controls miR expression at different levels. It directly regulates the transcription of several miRs and indirectly regulates their processing by regulating the expression of the miR processing components Dicer and DGCR8. In this review, we will discuss the recent findings on the miR–p63 interaction in epidermal biology, particularly focusing on the ΔNp63-dependent regulation of DGCR8 recently described in the ΔNp63−/− mouse. We provide a unified view of the current knowledge and discuss the apparent discrepancies and perspective therapeutic opportunities.en
dc.description.sponsorshipThis study was supported by the Medical Research Council, UK, by MIUR, MinSan/IDI-IRCCS (RF73, RF57) and by the Italian Association for Cancer Research (AIRC) investigator grants awarded to GM.en
dc.publisherNature Publishing Group for Congregazione dei Figli dell'Immacolata Concezione (CFIC), Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Dermopatico dell'Immacolata (IDI-IRCCS)en
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
dc.subjectmiR, microRNAen
dc.subjectIFE, interfollicular epidermisen
dc.subjectHFs, hair folliclesen
dc.subjectSG, sebaceous glandsen
dc.subjectSC, stem cellen
dc.subjectPAK, p21-activated kinasesen
dc.subjectIPSC, induced pluripotent stem cellen
dc.subjectMEF, mouse embryonic fibroblasten
dc.subjectECM, extracellular matrixen
dc.subjectK, keratinen
dc.titleMicroRNAs and p63 in epithelial stemnessen
dc.typeJournal Articleen
dc.description.versionPublisher Versionen
Appears in Collections:Published Articles, MRC Toxicology Unit

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