Please use this identifier to cite or link to this item:
Title: An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids
Authors: Amey, J. S.
O'Reilly, A. O.
Burton, Mark J.
Puinean, A. M.
Mellor, I. R.
Duce, I. R.
Field, L. M.
Wallace, B. A.
Williamson, M. S.
Davies, T. G. E.
First Published: 27-Jan-2015
Publisher: Wiley, Federation of European Biochemical Societies
Citation: FEBS Letters, 2015, 589 (5), pp. 598-607
Abstract: We describe the identification in aphids of a unique heterodimeric voltage-gated sodium channel which has an atypical ion selectivity filter and, unusually for insect channels, is highly insensitive to tetrodotoxin. We demonstrate that this channel has most likely arisen by adaptation (gene fission or duplication) of an invertebrate ancestral mono(hetero)meric channel. This is the only identifiable voltage-gated sodium channel homologue in the aphid genome(s), and the channel's novel selectivity filter motif (DENS instead of the usual DEKA found in other eukaryotes) may result in a loss of sodium selectivity, as indicated experimentally in mutagenised Drosophila channels.
DOI Link: 10.1016/j.febslet.2015.01.020
ISSN: 0014-5793
eISSN: 1873-3468
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright 2015 The Authors. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies. This is an open access article under the CC BY license ( by/4.0/).
Description: Supplementary data associated with this article can be found, in the online version, at
Appears in Collections:Published Articles, Dept. of Cell Physiology and Pharmacology

Files in This Item:
File Description SizeFormat 
Amey_et_al-2015-FEBS_Letters.pdfPublisher version2.91 MBAdobe PDFView/Open

Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.