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|Title:||Chronic Aspergillus fumigatus colonisation of the paediatric cystic fibrosis airway is common and may be associated with a more rapid decline in lung function|
Saunders, Rosalind V.
Modha, Deborah E.
|Publisher:||Oxford University Press (OUP)|
|Citation:||Medical Mycology, 2016 (Advance Access)|
|Abstract:||Filamentous fungi are commonly isolated from the respiratory tract of CF patients, but their clinical significance is uncertain and the reported incidence variable. We report on the degree of Aspergillus fumigatus airway colonization in a tertiary pediatric CF cohort, evaluate the sensitivity of routine clinical sampling at detecting A. fumigatus, and compare lung function of A. fumigatus-colonized and non-colonized children. We carried out an 8-year retrospective cohort analysis using local databases, examining 1024 respiratory microbiological specimens from 45 children. Nineteen (42%) had a positive A. fumigatus culture at least once during the 8-year period, with 10 (22%) children persistently colonized. Overall, 29% of 48 bronchoalveolar lavage (BAL) samples tested positive for A. fumigatus, compared with 14% of 976 sputum samples. Of 33 children for whom lung function data were available during the study period, seven were classed as having severe lung disease, of whom four (57%) were persistently colonized with A. fumigatus. We conclude that chronic A. fumigatus colonization of the CF airway is common, and may be associated with worse lung function. In our practice, BAL appears superior at detecting lower airway A. fumigatus compared to sputum samples.|
|Embargo on file until:||17-Jan-2017|
|Rights:||Copyright © The Author 2016. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: email@example.com. This is a pre-copyedited, author-produced PDF of an article accepted for publication in Medical Mycology following peer review. The version of record Med Mycol (2016) is available online at: dx.doi.org/10.1093/mmy/myv119|
|Description:||The file associated with this record is under a 12-month embargo from publication in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.|
|Appears in Collections:||Published Articles, Dept. of Infection, Immunity and Inflammation|
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|Saunders et al_MedMycol_final.doc||Post-review (final submitted)||395.5 kB||Microsoft Word||View/Open|
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